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KMID : 0438219780150030313
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Korea University Medical Journal
1978 Volume.15 No. 3 p.313 ~ p.321
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Brain compression and increased intracranial pressure
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Abstract
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Brain compression was experimentally induced in rabbits by an expansion of supratentorial epidural laminaria which is used in gynecological practice to dilate uterine cervical canal and has specific nature of increase in its volumn on contact with water. Histological studies were carried out on the compressed brain tissue.
Cerebral edema occured in response to the cerebral compression. Findings of generalized and regional cerebral edema were macroscopically observed in the compressed brain. The white matter was increased more in bluk than in the gray matter and looked wet and often slightly yellow.
Histopathological picture of the brain under the compression revealed several different degree of cerebral damage according to the sequence of time.
In the group of 12 hour´s compression, there were areas of detachment of the meninges. Vascular congestion and edema of the plexiform layer and a moderate degree of chromatolysis of neuronal cell and mild gliosis in the moleculogranular layer.
In the group of 24 hour´s compression, a thicking of the meninges due to exudative inflammatory
reaction was observed. Underlying plexiform layer disclosed rather prominent gliosis and the moleculogranular layer showed a mild chromatolysis.
In the group of 48 hour´s compression, the lesion revealed rather marked acute exudative infla mmatory change of the meninges. Underlying plexiform layer was atrophic with gliosis, and molecu-
logranular layer showed rather marked chromatolysir, of neuronal cell with mild multifocal infiltration of neutrophil and congestion.
The cerebrovascular architecture in various portions of the brain compressed by the mass was asessed by intravascular staining with benzidinoe. Complate collapse and thrombosiss of large surface and perforating vessel immediately subjacent to the mass were prominent. The hemorrhage and severe capillary obliteration of underlying compressed brain substance was also observed.
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